Perspective
Nature Reviews Drug Discovery 5, 115-121 (February 2006) | doi:10.1038/nrd1960
Innovation: Artificial viruses: a nanotechnological approach to gene delivery
Enrico Mastrobattista1, Marieke A. E. M. van der Aa1, Wim E. Hennink1 & Daan J. A. Crommelin1 About the authors
Abstract
Nanotechnology is a rapidly expanding multidisciplinary field in which highly sophisticated nanoscale devices are constructed from atoms, molecules or (macro)molecular assemblies. In the field of gene medicine, systems for delivering nucleic acids are being developed that incorporate virus-like functions in a single nanoparticle. Although their development is still in its infancy, it is expected that such artificial viruses will have a great impact on the advancements of gene therapeutics.
Author affiliations
- The authors are in the Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands.
Correspondence to: Enrico Mastrobattista1 Email: e.mastrobattista@pharm.uu.nl
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Toward Synthetic Viruses: Endosomal pH-Triggered Deshielding of Targeted Polyplexes Greatly Enhances Gene Transfer in vitro and in vivoMolecular Therapy Original Article
