FIGURE 3 | Rate of target innovation.

From the following article:

How many drug targets are there?

John P. Overington, Bissan Al-Lazikani and Andrew L. Hopkins

Nature Reviews Drug Discovery 5, 993-996 (December 2006)

doi:10.1038/nrd2199

How many drug targets are there?

The y-axis represents the year of first drug launch against each target, and the x-axis is the year of each subsequent drug release, with the plot ordered so that more recently 'drugged' targets are shown at a higher y ordinate. Region a reflects periods of high target innovation (after 1982) while region b is predominantly the re-use of established mechanisms. The rate of new protein families per year is 1.9.

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