Figures and Tables

From the following article:

Mining the Wnt pathway for cancer therapeutics

Nick Barker and Hans Clevers

Nature Reviews Drug Discovery 5, 997-1014 (December 2006)

doi:10.1038/nrd2154

Figure 1 - Mining the Wnt pathway for cancer therapeutics

Figure 1

An overview of the Wnt signalling pathway.

Figure 2 - Mining the Wnt pathway for cancer therapeutics

Figure 2

Routes to aberrant activation of Wnt signalling in cancer cells.

Figure 3 - Mining the Wnt pathway for cancer therapeutics

Figure 3

Accumulation of beta-catenin in adenomas.

Figure 4 - Mining the Wnt pathway for cancer therapeutics

Figure 4

A cell-based assay for screening compound libraries for small-molecule inhibitors of the Wnt pathway.

Figure 5 - Mining the Wnt pathway for cancer therapeutics

Figure 5

Secondary assays for evaluating potential Wnt inhibitors identified in primary high-throughput screens.

Table 1 - Mining the Wnt pathway for cancer therapeutics

Table 1

Common events linked with aberrant activation of Wnt signalling

Table 2 - Mining the Wnt pathway for cancer therapeutics

Table 2

Small-molecule inhibitors of the Wnt signalling pathway