Review
Nature Reviews Drug Discovery 5, 956-970 (November 2006) | doi:10.1038/nrd2075
Subject Category: Model organisms
Model organisms: Drug discovery in dementia: the role of rodent models
Debby Van Dam1 & Peter Paul De Deyn2 About the authors
Abstract
Recent advances in the understanding of the pathophysiological mechanisms underlying Alzheimer's disease have pointed to novel strategies for drug development. Animal models have contributed considerably to these advances, and will have a key role in the evaluation of therapeutics that could have the potential not just to alleviate the dementia associated with Alzheimer's disease, but to modify the disease process. Here, we summarize and critically evaluate current rodent models of dementia, and discuss their role in drug discovery and development.
- View At a Glance
Author affiliations
-
Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
Email: debby.vandam@ua.ac.be -
Department of Neurology / Memory Clinic, Middelheim General Hospital, ZNA, Lindendreef 1, 2020 Antwerp, Belgium
Email: peter.dedeyn@ua.ac.be
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
The players on the γ-secretase teamNature Medicine News and Views (01 Jul 2006)
Teasing out the tanglesNature Medicine News and Views (01 Jul 2006)
See all 9 matches for News And ViewsRESEARCH
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β?amyloid precursor protein geneNature Genetics Article (01 Jun 1992)
See all 20 matches for Research
