Figures and Tables

From the following article:

Epigenetic therapy of cancer: past, present and future

Christine B. Yoo & Peter A. Jones

Nature Reviews Drug Discovery 5, 37-50 (January 2006)

doi:10.1038/nrd1930

Figure 1 - Epigenetic therapy of cancer: past, present and future

Figure 1

Epigenetic gene silencing in cancer.

Figure 2 - Epigenetic therapy of cancer: past, present and future

Figure 2

Reactivation of aberrantly silenced genes by DNA methylation inhibitors.

Figure 3 - Epigenetic therapy of cancer: past, present and future

Figure 3

Mechanism-based inhibition of DNA methylation by cytosine analogues.

Figure 4 - Epigenetic therapy of cancer: past, present and future

Figure 4

Effects of HDAC inhibitors in human cancer.

Table 1 - Epigenetic therapy of cancer: past, present and future

Table 1

DNA-methylation inhibitors: nucleoside analogues

Table 2 - Epigenetic therapy of cancer: past, present and future

Table 2

DNA-methylation inhibitors: non-nucleoside analogues

Table 3 - Epigenetic therapy of cancer: past, present and future

Table 3

Histone-deacetylase inhibitors: short-chain fatty acids and hydroxamic acids

Table 4 - Epigenetic therapy of cancer: past, present and future

Table 4

Histone-deacetylase inhibitors: cyclic tetrapeptides and benzamides