Review
Nature Reviews Drug Discovery 4, 569-580 (July 2005) | doi:10.1038/nrd1777
Ageing and metabolism: drug discovery opportunities
Rory Curtis1, Bard J. Geesaman1 & Peter S. DiStefano1 About the authors
Abstract
There has recently been significant progress in our understanding of the mechanisms that regulate ageing, and it has been shown that changes in single genes can dramatically extend lifespan and increase resistance to many diseases. Furthermore, many of these genes belong to evolutionarily conserved pathways that also control energy metabolism. In this review, we describe the shared molecular machinery that regulates ageing and energy metabolism. Although drugs to slow ageing face severe regulatory hurdles, it is likely that an understanding of ageing pathways will help to identify novel drug targets to treat metabolic disorders and other age-related diseases.
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Author affiliations
- Elixir Pharmaceuticals, One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, USA.
Correspondence to: Peter S. DiStefano1 Email: pdistefano@elixirpharm.com
Published online 24 June 2005
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