Table of contents
In this issue
p89 | doi:10.1038/nrd1654
Editorial: A look on the bright side
p91 | doi:10.1038/nrd1644
News and Analysis
News
2004 approvals: the demise of the blockbuster? | PDF (318 KB)
p93 | doi:10.1038/nrd1648
News
Iressa failure raises fears about accelerated approvals | PDF (298 KB)
p94 | doi:10.1038/nrd1649
News
Fine print TRIPS up multinational and Indian companies | PDF (318 KB)
p94 | doi:10.1038/nrd1650
News in Brief
Patent watch
Alza's patent upheld | PDF (0KB)
p96 | doi:10.1038/nrd1651
Patent watch
How safe is Safe harbour? | PDF (0KB)
p96 | doi:10.1038/nrd1652
Patent watch
Promoter sequence not novel | PDF (318 KB)
p96 | doi:10.1038/nrd1653
Patent primer
Patent infringement | PDF (318 KB)
p97 | doi:10.1038/nrd1638
An Audience With
Sir John Sulston | PDF (318 KB)
p98 | doi:10.1038/nrd1646
From the analyst's couch
Female sexual dysfunction | PDF (298 KB)
p99 | doi:10.1038/nrd1636
Fresh from the Pipeline
Natalizumab | PDF (298 KB)
p101 | doi:10.1038/nrd1637
Research Highlights
Antibacterial drugs: Tackling tuberculosis | PDF (81 KB)
p103 | doi:10.1038/nrd1645
Lead Optimization: Improving natural strength | PDF (219 KB)
p1041 | doi:10.1038/nrd1641
Psoriasis: STAT3: new target | PDF (121 KB)
p1041 | doi:10.1038/nrd1642
Antiviral Drugs: Coordinated effort targets resistance | PDF (150 KB)
p1051 | doi:10.1038/nrd1639
Structure-Based Drug Design: Seeking selectivity | PDF (98 KB)
p1061 | doi:10.1038/nrd1640
News in Brief
Eye Disorders | Neurodegenerative disease | Screening | Infectious diseases | PDF (98 KB)
p1061 | doi:10.1038/nrd1643
Reviews
The histamine H3 receptor: from gene cloning to H3 receptor drugs
Rob Leurs, Remko A. Bakker, Henk Timmerman & Iwan J. P. de Esch
p107 | doi:10.1038/nrd1631
Article series: A guide to drug discovery
A guide to drug discovery: Pricing medicines: theory and practice, challenges and opportunities
Nigel Gregson, Keiron Sparrowhawk, Josephine Mauskopf & John Paul
p121 | doi:10.1038/nrd1633
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn & Darryle D. Schoepp
p131 | doi:10.1038/nrd1630
Recent advances with liposomes as pharmaceutical carriers
Vladimir P. Torchilin
p145 | doi:10.1038/nrd1632
Perspectives
Article series: Model organisms
Opinion
What's wrong with our cancer models?
Alexander Kamb
p161 | doi:10.1038/nrd1635
Opinion
Depression, antidepressants and suicidality: a critical appraisal
Julio Licinio & Ma-Li Wong
p165 | doi:10.1038/nrd1634
