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Review
Nature Reviews Drug Discovery 4, 977–987 (1 December 2005) | doi:10.1038/nrd1901
Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms
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Abstract
Chronic inflammation is a key feature of vascular disease states such as atherosclerosis. Multiple clinical studies have shown that a class of medications termed statins lower cardiovascular morbidity and mortality. Originally developed to lower serum cholesterol, increasing evidence suggests that these medications have potent anti-inflammatory effects that contribute to their beneficial effects in patients. Here, we discuss the clinical and experimental evidence underlying the anti-inflammatory effects of these agents.
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