Nature Reviews Drug Discovery 3, 801-808 (September 2004) | doi:10.1038/nrd1500

OpinionBiochemical mechanisms of drug action: what does it take for success?

David C. Swinney1  About the author


Drug discovery is extremely difficult. There are many unanticipated scientific, medical and business challenges to every drug discovery programme. It is important to increase our understanding of the fundamental properties of effective drugs so that we can anticipate potential problems in developing new agents. This article addresses potential drug discovery and development risks associated with the biochemical mechanism of drug action, and proposes simple rules to minimize these risks.

Author affiliations

  1. Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, California 94304, USA.


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