Review
Nature Reviews Drug Discovery 3, 785-796 (September 2004) | doi:10.1038/nrd1494
Nanosuspensions in drug delivery
Barrett E. Rabinow1 About the author
Abstract
A surprisingly large proportion of new drug candidates emerging from drug discovery programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called 'brickdust' candidates can now be rescued by formulating them into crystalline nanosuspensions. In the process of overcoming issues involving solubility, additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated. As such, insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future.
- View At a Glance
Author affiliations
-
Senior Director, Strategic Technical Development, Baxter Healthcare Corporation, Baxter Technology Park, Round Lake, Illinois 60073, USA.
Email: barrett_rabinow@baxter.com
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Temporal changes in allele frequency, genetic variation and inbreeding depression in small populations of the guppy, Poecilia reticulataHeredity Original Article
Formation and enhanced biocidal activity of water-dispersable organic nanoparticlesNature Nanotechnology Letter (01 Aug 2008)
