FIGURE 1 | Estimates of patients treated for major bleeding events and haemophilia prophylaxis in the industrialized world (2002).

The histogram represents a meta-analysis (source: A Yeomans, P. Bishop, D. Adler; ZymoGenetics, Inc., 2004) of the number of haemophilia (A and B) patients and patients that experienced a significant bleeding event requiring intervention in 2002. Estimates for the average blood loss and average red-blood-cell transfusion (Tx) requirements for these events vary greatly. Each category represents a sum of subsets as defined and does not necessarily represent the total patient population of the category. Haemophilia: estimated number of people with haemophilia receiving factor VIII (FVIII) and FIX prophylaxis (does not indicate number of bleeds or treatment events). Head trauma: incidence of intracranial bleeding as a result of head trauma. Urogenital (surgeries requiring Tx): hysterectomies and prostatectomies. Gastrointestinal (surgeries requiring Tx): colorectal surgeries (open and laparoscopic); bowel resections; liver transplants and partial hepatectomies; non-variceal and oesophageal variceal bleeding. Trauma: all non-head traumas requiring Tx. Cerebral vascular disease: intracerebral, subarachnoid and subdural haemorrhages; gliomas, astrocytomas, meningiomas and arterial malformation surgeries, and other intracranial surgery. Obstetrics: postpartum haemorrhages (that is, >500 ml blood loss during a vaginal delivery or >1,000 ml blood loss during a caesarian section). Cardiac (surgeries): surgeries receiving Tx; bypass grafts and valves replacement only. Orthopaedic: all surgeries receiving Tx; that is, hip and knee replacement and spinal fusions. Some life-threatening bleeding conditions are omitted; for example, some cancers and pulmonary haemorrhage.

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