Table of contents


In this issue

p537 | doi:10.1038/nrd1459

Editorial: G-protein-coupled receptors: the devil is in the detail

p539 | doi:10.1038/nrd1457

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News and Analysis

News

How academia can help drug discovery | PDF (81 KB)

p541 | doi:10.1038/nrd1462

Patent watch

New instructions for old invention not patentable | PDF (72 KB)

p544 | doi:10.1038/nrd1448

Patent watch

Prior art | PDF (72 KB)

p544 | doi:10.1038/nrd1449

Patent watch

Not for sale...yet | PDF (72 KB)

p544 | doi:10.1038/nrd1452

Patent Primer

Establishing novelty and relevant prior art | PDF (52 KB)

p545 | doi:10.1038/nrd1446

An Audience With

Robert S. Langer | PDF (55 KB)

p546 | doi:10.1038/nrd1453

From the analyst's couch

Targeted lung cancer therapies | PDF (117 KB)

p547 | doi:10.1038/nrd1444

Fresh from the Pipeline

Cetuximab | PDF (101 KB)

p549 | doi:10.1038/nrd1445

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Research Highlights

Kinases: Overcoming inhibition | PDF (93 KB)

p551 | doi:10.1038/nrd1456

Structural biology: Not so crystal clear | PDF (284 KB)

p552 | doi:10.1038/nrd1451

Muscular dystrophy: A LARGE dose of sugar | PDF (284 KB)

p552 | doi:10.1038/nrd1455

High-throughput screening: Free your assay | PDF (205 KB)

p553 | doi:10.1038/nrd1447

In brief

Anticancer drugs | Lead identification | Imaging | PDF (117 KB)

p554 | doi:10.1038/nrd1450

Cardioprotection: All roads lead to GSK-3beta | PDF (117 KB)

p554 | doi:10.1038/nrd1460

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Reviews

A new modality for immunosuppression: targeting the JAK/STAT pathway

John J. O'Shea, Marko Pesu, Dominic C. Borie & Paul S. Changelian

p555 | doi:10.1038/nrd1441

Novel therapeutic approaches for heart failure by normalizing calcium cycling

Xander H. T. Wehrens & Andrew R. Marks

p565 | doi:10.1038/nrd1440

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Twenty Questions

The state of GPCR research in 2004

Clare Ellis & The Nature Reviews Drug Discovery GPCR Questionnaire Participants.

p577 | doi:10.1038/nrd1458

Career focus

The genomics evolution

Simon Frantz

p629 | doi:10.1038/nrd1454

Natureview: Reviews and comment from the nature publishing group

| doi:10.1038/nrd1461

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