Table of contents
In this issue
p373 | doi:10.1038/nrd1402
Editorial: New Horizons in chemical space
p375 | doi:10.1038/nrd1401
News and Analysis
News
Expanded EU presents promise and challenges
p377 | doi:10.1038/nrd1403
News
News
FDA publishes analysis of the pipeline problem
p379 | doi:10.1038/nrd1404
Patent watch
No commercial break for combination treatment
p380 | doi:10.1038/nrd1390
Patent watch
Patent office decision over restriction requirement scrutinized
p380 | doi:10.1038/nrd1393
Patent watch
Chiron claims against Genentech patent dismissed again
p380 | doi:10.1038/nrd1394
Patent primer
Patentability in the United States
p381 | doi:10.1038/nrd1388
An Audience With
Allen D. Roses
p382 | doi:10.1038/nrd1400
From the analyst's couch
Monoclonal antibodies market
p383 | doi:10.1038/nrd1386
Fresh from the Pipeline
Atomoxetine hydrochloride
p385 | doi:10.1038/nrd1387
Research Highlights
Respiratory disease: Timing is everything
p387 | doi:10.1038/nrd1397
Cardiovascular disease: Plumbing for the heart
p388 | doi:10.1038/nrd1392
Whole organism screening: Zebrafish reduce drug discovery gridlock
p388 | doi:10.1038/nrd1398
Chemical genetics: New use for the cellular dustbin
p389 | doi:10.1038/nrd1389
Neurodegenerative diseases: Metabolite-mediated misfolding
p390 | doi:10.1038/nrd1391
In brief
Chemical libraries | Inflammatory bowel disease | Antibacterial drugs
p390 | doi:10.1038/nrd1395
Reviews
Article series: Case Histories
Case history
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
Napoleone Ferrara, Kenneth J. Hillan, Hans-Peter Gerber & William Novotny
p391 | doi:10.1038/nrd1381
Inflammatory Resolution: new opportunities for drug discovery
Derek W. Gilroy, Toby Lawrence, Mauro Perretti & Adriano G. Rossi
p401 | doi:10.1038/nrd1383
Key factors in the rising cost of new drug discovery and development
Michael Dickson & Jean Paul Gagnon
p417 | doi:10.1038/nrd1382
Development of novel targeted therapies in the treatment of malignant glioma
Jeremy N. Rich & Darell D. Bigner
p430 | doi:10.1038/nrd1380
Perspectives
Innovation
Current and future applications of the capsule camera
Waqar A. Qureshi
p447 | doi:10.1038/nrd1385
Opinion
Prospects for productivity
Bruce Booth & Rodney Zemmel
p451 | doi:10.1038/nrd1384
Careers and Recruitment
Career focus
FDA head wanted, wimps need not apply
Henry I. Miller
p459 | doi:10.1038/nrd1396
Corrigendum: Amp kinase and malonyl-coa: Targets for therapy of the metabolic syndrome
Neil Ruderman & Marc Prentki
| doi:10.1038/nrd1412
