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Nature Reviews Drug Discovery 3, 239–278 (1 March 2004) | doi:10.1038/nrd1361
The state of ion channel research in 2004
Abstract
Ion channels represent a rich and relatively untapped vein of future therapeutic targets, but realizing their potential is proving harder than first imagined. The unexpected setbacks, resulting in an ever-lengthening list of failed drug development programmes based around ion channels, highlight our need for a greater understanding of the underlying biology and physiology of ion channel function. To this end, Nature Reviews Drug Discovery has attempted to survey the field by posing 20 questions of fundamental importance to the development of the field to 20 of the world's leading authorities on ion channel research, and here we present their answers.
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