Table of contents


In this issue

p245 | doi:10.1038/nrd1083

Editorial: Costing drug development

p247 | doi:10.1038/nrd1070

Top

Research Highlights

Research funding: The ties that bind

p249 | doi:10.1038/nrd1071

Therapeutic proteins: Polymer-perfect proteins

p250 | doi:10.1038/nrd1074

Chemical genetics: Combichem leads for asthma

p250 | doi:10.1038/nrd1076

Anticoagulants: The clot thickens

p251 | doi:10.1038/nrd1078

Structure-based drug design: An ACE surprise

p252 | doi:10.1038/nrd1072

Neurodegenrative disease: Come on everybody, do the congo!

p252 | doi:10.1038/nrd1077

Lead discovery: Get a grip

p253 | doi:10.1038/nrd1075

In brief

Anticancer Drugs | Computational Chemistry | Stroke | Anticancer Drugs

p253 | doi:10.1038/nrd1079

Protein folding diseases: Raising the bar

p254 | doi:10.1038/nrd1073

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News and Analysis

From the analyst's couch

Biotech's fallen angels

p255 | doi:10.1038/nrd1069

Fresh from the Pipeline

Teriparatide

p257 | doi:10.1038/nrd1068

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Reviews

Article series: A guide to drug discovery

A guide to drug discovery: Designing screens: how to make your hits a hit

W. Patrick Walters & Mark Namchuk

p259 | doi:10.1038/nrd1063

Targeting the CREB pathway for memory enhancers

Tim Tully, Rusiko Bourtchouladze, Rod Scott & John Tallman

p267 | doi:10.1038/nrd1061

Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets

Donald M. Coen & Priscilla A. Schaffer

p278 | doi:10.1038/nrd1032

Challenges for the oral delivery of macromolecules

Michael Goldberg & Isabel Gomez-Orellana

p289 | doi:10.1038/nrd1067

Issues and progress with protein kinase inhibitors for cancer treatment

Janet Dancey & Edward A. Sausville

p296 | doi:10.1038/nrd1066

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Perspectives

Timeline

Discovering risperidone: the LSD model of psychopathology

Francis C. Colpaert

p315 | doi:10.1038/nrd1062

Timeline

A brief history of novel drug discovery technologies

Leland J. Gershell & Joshua H. Atkins

p321 | doi:10.1038/nrd1064

Natureview: Reviews and comment from the nature publishing group

p329 | doi:10.1038/nrd1081

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Careers and Recruitment

Screening the right candidate

Simon Frantz

p331 | doi:10.1038/nrd1082

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