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Nature Reviews Drug Discovery 2, 1019–1025 (1 December 2003) | doi:10.1038/nrd1256
Metabolic engineering for drug discovery and development
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Abstract
Metabolic engineering has been defined as the redirection of metabolic pathways using genetic manipulation. Since the emergence of metabolic engineering science in the early 1980s, the field has made notable strides not only at a conceptual level, but also with regard to translating these concepts into practical products and processes. Today, metabolic engineering plays an important role in the generation of fuels from renewable resources, the conversion of agricultural raw materials (for example, corn syrup) into bulk and specialty chemicals, and the discovery, development and scale-up of therapeutically useful products. This article focuses on recent advances in the last category. Specifically, we review the impact that converging developments in genetic engineering and biosynthetic chemistry are having on natural-product drug discovery.
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