Table of contents


In This Issue

p1 | doi:10.1038/nrd992

Editorial: Guiding drug discovery through 2003

p3 | doi:10.1038/nrd1003

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Research Highlights

Obesity: A high dose of JuNK for fat mice

p5 | doi:10.1038/nrd993

Biotechnology: Putting a finger on gene expression

p6 | doi:10.1038/nrd994

Muscular degeneration: Body building best without myostatin

p6 | doi:10.1038/nrd995

Amyloid diseases: Assembly instructions

p7 | doi:10.1038/nrd996

Nsaids: Better design through chemistry

p8 | doi:10.1038/nrd997

Obesity: It goes straight to my hips

p8 | doi:10.1038/nrd998

Bone diseases: Leptin bares our bones, sympathetically

p9 | doi:10.1038/nrd999

Adrenoceptor pharmacology: Variety is the spice of life

p10 | doi:10.1038/nrd1002

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News and Analysis

From the analyst's couch

Antithrombotic drug market

p11 | doi:10.1038/nrd966

Fresh from the Pipeline

Drotrecogin alpha (activated)

p13 | doi:10.1038/nrd991

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Focus on: Atherothrombosis

Reviews

Scientific and therapeutic advances in antiplatelet therapy

Deepak L. Bhatt & Eric J. Topol

p15 | doi:10.1038/nrd985

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Reviews

Scientific and therapeutic advances in antiplatelet therapy

Deepak L. Bhatt & Eric J. Topol

p15 | doi:10.1038/nrd985

The emerging field of nanotube biotechnology

Charles R. Martin & Punit Kohli

p29 | doi:10.1038/nrd988

Knockouts model the 100 best-selling drugs—will they model the next 100?

Brian P. Zambrowicz & Arthur T. Sands

p38 | doi:10.1038/nrd987

Therapeutic antibodies for human diseases at the dawn of the twenty-first century

Ole Henrik Brekke & Inger Sandlie

p52 | doi:10.1038/nrd984

Article series: A guide to drug discovery

A guide to drug discovery: Target selection in drug discovery

Jonathan Knowles & Gianni Gromo

p63 | doi:10.1038/nrd986

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Perspectives

Timeline

The Common Technical Document: the changing face of the New Drug Application

Justina Molzon

p71 | doi:10.1038/nrd990

Outlook

The further evolution of biotech

Tricia Nagle, Carilee Berg, Rena Nassr & Kevin Pang

p75 | doi:10.1038/nrd989

Natureview: Reviews and comment from the nature publishing group

p81 | doi:10.1038/nrd1004

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Careers and Recruitment

What makes a good forecaster?

John Earl

p83 | doi:10.1038/nrd1005

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