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Key factors for successful data integration in biomarker research

Nature Reviews Drug Discovery volume 15, pages 369–370 (2016)Cite this article

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Abstract

Integrating a wide range of biomedical data such as that rapidly emerging from the use of next-generation sequencing is expected to have a key role in identifying and qualifying new biomarkers to support precision medicine. Here, we highlight some of the challenges for biomedical data integration and approaches to address them.

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References

  1. Marti-Solano, M. et al. Integrative knowledge management to enhance pharmaceutical R&D. Nat. Rev. Drug Discov. 13, 239–240 (2014).

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Acknowledgements

P. Groth, J. Saric, P. Scordis, M. Grossman, J. Quackenbush, B. Williams-Jones, R. Schneider, and A. Pai gave presentations and are acknowledged together with the rest of the participants for their valuable input to the ideas in this article (see Supplementary information S1 (box)).

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Authors and Affiliations

  1. Bayer Pharma AG, Müllerstrasse 178, Berlin, 13342, Germany

    Antigoni Elefsinioti, Tanja Bellaire, Henrik Seidel, Gernot Goeller & David Henderson

  2. Bristol-Myers Squibb, Princeton, 08543, New Jersey, USA

    Albert Wang & Anastasia Christianson

  3. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany

    Karsten Quast

  4. F. Hoffmann-La Roche, 10016, New Jersey, USA

    Michael Braxenthaler

  5. AstraZeneca Personalized HealthCare and Biomarkers, Pepparedsleden 1, Mölndal, SE-431 83, Sweden

    Joachim Reischl

  6. Former affiliation: Bayer Pharma AG, Müllerstrasse 178, 13342 Berlin, Germany.,

    Joachim Reischl

Authors
  1. Antigoni Elefsinioti
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  2. Tanja Bellaire
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  3. Albert Wang
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  4. Karsten Quast
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  5. Henrik Seidel
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  6. Michael Braxenthaler
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  7. Gernot Goeller
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  8. Anastasia Christianson
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  9. David Henderson
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  10. Joachim Reischl
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Corresponding author

Correspondence to Antigoni Elefsinioti.

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Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary information S1 (box)

Agenda and participants for “Data integration and biomarker translational research in pharmas” The workshop, organized by Bayer Pharma, was held on 10th-11th of March 2015 at the Maritim proArte Hotel, Berlin, Germany. (PDF 205 kb)

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Elefsinioti, A., Bellaire, T., Wang, A. et al. Key factors for successful data integration in biomarker research. Nat Rev Drug Discov 15, 369–370 (2016). https://doi.org/10.1038/nrd.2016.74

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