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Assessing the relative efficacy of new drugs: an emerging opportunity

Nature Reviews Drug Discovery volume 14, pages 443–444 (2015)Cite this article

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Abstract

The increasing availability of individual-level data from clinical trials could allow the relative efficacy of new drugs to be assessed in a robust, cost-effective and timely way.

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References

  1. Bombardier, C. et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N. Engl. J. Med. 343, 1520–1528 (2000).

    Article  CAS  Google Scholar 

  2. EUnetHTA WP5 Joint Action 2 Strand A. Rapid Relative Effectiveness Assessment of pharmaceuticals. Pilot assessment using the HTA Core Model® for rapid relative effectiveness assessment: canagliflozin for the treatment of type 2 diabetes mellitus [online]

  3. Schneeweiss S. et al. Comparative efficacy and safety of new oral anticoagulants in patients with atrial fibrillation. Circ. Cardiovasc. Qual. Outcomes 5, 480–486 (2012).

    Article  Google Scholar 

  4. Strom, B. et al. Data sharing, year 1 — access to data from industry-sponsored clinical trials. N. Engl. J. Med. 371, 2052–2054 (2014).

    Article  Google Scholar 

  5. Keener, A. B. Group seeks standardisation for what clinical trials must measure. Nature Med. 20, 798–799 (2014).

    Article  CAS  Google Scholar 

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Acknowledgements

S.S. is partially funded by grants/contracts from the Patient-Centered Outcomes Research Institute, the US Food and Drug Administration and the NIH.

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Authors and Affiliations

  1. European Medicines Agency, 30 Churchill Place, Canary Wharf, E14 5EU, London, UK

    Hans-Georg Eichler, Andrew Thomson & Irmgard Eichler

  2. Division of Pharmacoepidemiology, Department of Medicine, Brigham and Womens Hospital and Harvard Medical School, 1 Brigham Circle, Boston, 02120, Massachusetts, USA

    Sebastian Schneeweiss

Authors
  1. Hans-Georg Eichler
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  2. Andrew Thomson
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  3. Irmgard Eichler
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  4. Sebastian Schneeweiss
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Corresponding author

Correspondence to Hans-Georg Eichler.

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Competing interests

S. S. is a consultant to WHISCON, LLC and to Aetion, Inc., a software manufacturer in which he also owns equity. He is the principal investigator of investigator-initiated grants to the Brigham and Women's Hospital from Novartis, Genentech and Boehringer Ingelheim that are unrelated to the topic of this study.

Supplementary information

Supplementary information S1 (figure)

The trade-off between scientific (internal) validity and feasibility of study designs for Relative Efficacy Assessment (REA). (PDF 111 kb)

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Eichler, HG., Thomson, A., Eichler, I. et al. Assessing the relative efficacy of new drugs: an emerging opportunity. Nat Rev Drug Discov 14, 443–444 (2015). https://doi.org/10.1038/nrd4664

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