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Nanomedicine: is the wave cresting?

The field of nanomedicine has grown rapidly in recent years, but several issues are emerging that could constrain its future evolution, particularly if they are not appropriately acknowledged and the potential of nanomedicine is oversold.

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References

  1. Venditto, V. J. & Szoka, F. C. Jr. Cancer nanomedicines: So many papers so few drugs! Adv. Drug Deliv. Rev. 1 Oct 2012 (doi:10.1016/j.addr.2012.09.038).

    Article  CAS  PubMed  Google Scholar 

  2. Duncan, R. & Gaspar, R. Nanomedicine(s) under the microscope. Mol. Pharm. 8, 2101–2141 (2011).

    Article  CAS  PubMed  Google Scholar 

  3. Chauhan, V. et al. Delivery of molecular and nanoscale medicine to tumors: barriers and strategies. Annu. Rev. Chem. Biomol. Eng. 2, 281–298 (2011).

    Article  CAS  PubMed  Google Scholar 

  4. Cheng, Z. et al. Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities. Science 338, 903–910 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rugo, H. S. et al. CALGB 40502/NCCTG N063H: randomized phase III trial of weekly paclitaxel (P) compared to weekly nanoparticle albumin bound nab-paclitaxel (NP) or ixabepilone (Ix) with or without bevacizumab (B) as first-line therapy for locally recurrent or metastatic breast cancer (MBC). J. Clin. Oncol. Abstr. S30, CRA1002 (2012).

    Article  Google Scholar 

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Rudy Juliano holds NIH grants in the area of delivery of antisense and siRNA oligonucleotides.

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Juliano, R. Nanomedicine: is the wave cresting?. Nat Rev Drug Discov 12, 171–172 (2013). https://doi.org/10.1038/nrd3958

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