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References
Eichler, H. G. et al. New drug approval success rate in Europe in 2009. Nature Rev. Drug Discov. 9, 355–356 (2010).
Paul, S. M. et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nature Rev. Drug Discov. 9, 203–214 (2010).
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All authors declare no conflict of interest relevant to the subject matter or materials discussed in the manuscript. This study was funded by the Dutch Top Institute Pharma Escher project (T6-202).The department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, has received unrestricted research funding from the Netherlands Organisation for Health Research and Development (ZonMW), the Dutch Health Care Insurance Board (CVZ), the Royal Dutch Pharmacists Association (KNMP), the private–public-funded Top Institute Pharma, including co-funding from universities, government, and industry, the EU Innovative Medicines Initiative (IMI), the EU seventh Framework Program (FP7), the Dutch Medicines Evaluation Board, the Dutch Ministry of Health and industry (including GlaxoSmithKline, Pfizer and others).
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Key variables and scores for development plan, clinical outcome and clinical relevance (PDF 160 kb)
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Putzeist, M., Mantel-Teeuwisse, A., Aronsson, B. et al. Factors influencing non-approval of new drugs in Europe. Nat Rev Drug Discov 11, 903–904 (2012). https://doi.org/10.1038/nrd3894
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DOI: https://doi.org/10.1038/nrd3894
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