TABLE 2 | Discovery of first-in-class NMEs by therapeutic area

From the following article:

How were new medicines discovered?

David C. Swinney & Jason Anthony

Nature Reviews Drug Discovery 10, 507-519 (July 2011)

doi:10.1038/nrd3480

Disease areaTarget-based screeningPhenotypic screeningBiologics
Infectious diseases371
Immune106
Cancer538
Central nervous system171
Metabolic322
Cardiovascular230
Gastrointestinal111
Others131
Rare diseases02 
NME, new molecular entity.

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