Table of contents


In this issue

p561 | doi:10.1038/nrd888

Editorial: New resources on the horizon

p563 | doi:10.1038/nrd889

Top

Research Highlights

Sleep control: Regular as clockwork

p565 | doi:10.1038/nrd876

Anticancer drugs: Next in line?

p566 | doi:10.1038/nrd878

Stress-related disorders: Controlling emotion

p566 | doi:10.1038/nrd887

Viral infections: Exchange control

p567 | doi:10.1038/nrd880

Heat-shock proteins: TNF in hot shocker

p568 | doi:10.1038/nrd879

Anticancer drugs: Deadly cargo

p568 | doi:10.1038/nrd881

In brief

Allergy | Cardiovascular disease | Anticancer drugs | Nanotechnology

p569 | doi:10.1038/nrd882

Adrenoceptor pharmacology: How the ligand changed its spots

p569 | doi:10.1038/nrd885

Lead identification: Best with both worlds?

p570 | doi:10.1038/nrd877

Top

News and Analysis

Patent watch

Electronic filing ready to go... | Hope for Genentech?

p570 | doi:10.1038/nrd883

From the analyst's couch

Value of novelty?

p571 | doi:10.1038/nrd884

Top

Reviews

New tools and concepts for modern organic synthesis

Steven V. Ley & Ian R. Baxendale

p573 | doi:10.1038/nrd871

CDKS and CKIS: Molecular targets for tissue remodelling

Elizabeth G. Nabel

p587 | doi:10.1038/nrd869

The use of constitutively active GPCRs in drug discovery and functional genomics

Derek T. Chalmers & Dominic P. Behan

p599 | doi:10.1038/nrd872

Endogenous kynurenines as targets for drug discovery and development

Trevor W. Stone & L. Gail Darlington

p609 | doi:10.1038/nrd870

Drugs targeting the renin–angiotensin–aldosterone system

Mohammad Amin Zaman, Suzanne Oparil & David A. Calhoun

p621 | doi:10.1038/nrd873

Top

Perspectives

Timeline

The emergence of the drug receptor theory

Andreas-Holger Maehle, Cay-Rüdiger Prüll & Robert F. Halliwell

p637 | doi:10.1038/nrd875

Opinion

A proposal for FDA reform

Henry I. Miller

p642 | doi:10.1038/nrd874

Natureview: Reviews and comment from the nature publishing group

p649 | doi:10.1038/nrd890

Top

Careers and Recruitment

Mass spectrometry in drug discovery and development

John Michnowicz

p651 | doi:10.1038/nrd886

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