Review
Nature Reviews Drug Discovery 1, 609-620 (August 2002) | doi:10.1038/nrd870
Endogenous kynurenines as targets for drug discovery and development
Trevor W. Stone1 & L. Gail Darlington2 About the authors
Abstract
The kynurenine pathway is the main pathway for tryptophan metabolism. It generates compounds that can modulate activity at glutamate receptors and possibly nicotinic receptors, in addition to some as-yet-unidentified sites. The pathway is in a unique position to regulate other aspects of the metabolism of tryptophan to neuroactive compounds, and also seems to be a key factor in the communication between the nervous and immune systems. It also has potentially important roles in the regulation of cell proliferation and tissue function in the periphery. As a result, the pathway presents a multitude of potential sites for drug discovery in neuroscience, oncology and visceral pathology.
- View At a Glance
Author affiliations
- Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK.
- Epsom General Hospital, Dorking Road, Epsom, Surrey KT18 7EG, UK.
Correspondence to: Trevor W. Stone1 Email: T.W.Stone@bio.gla.ac.uk
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated RESEARCH |
