Review
Nature Reviews Drug Discovery 1, 276-286 (April 2002) | doi:10.1038/nrd770
Obesity therapy: altering the energy intake-and-expenditure balance sheet
Vivion E. F. Crowley1, Giles S. H. Yeo2 & Stephen O'Rahilly1 About the authors
Abstract
Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers. The psychological consequences of obesity can range from lowered self-esteem to clinical depression. Despite the high prevalence of obesity and the many advances in our understanding of how it develops, current therapies have persistently failed to achieve long-term success. This review focuses on how fat mass can be reduced by altering the balance between energy intake and expenditure.
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Author affiliations
- University Departments of Medicine and Clinical Biochemistry, Addenbrooke's Hospital, Cambridge CB2 2QR, UK.
- Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 2XY, UK.
Correspondence to: Stephen O'Rahilly1 Email: sorahill@hgmp.mrc.ac.uk
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