Figures and Tables

From the following article:

Structural biology of insulin and IGF1 receptors: implications for drug design

Pierre De Meyts & Jonathan Whittaker

Nature Reviews Drug Discovery 1, 769-783 (October 2002)

doi:10.1038/nrd917

Figure 1 - Structural biology of insulin and IGF1 receptors: implications for drug design

Figure 1

Structures of the insulin and IGF1 receptors and their ligands.

Figure 2 - Structural biology of insulin and IGF1 receptors: implications for drug design

Figure 2

Structure of the tyrosine-kinase domain of the insulin receptor.

Figure 3 - Structural biology of insulin and IGF1 receptors: implications for drug design

Figure 3

Summary of the various electron-microscopic studies of the insulin receptor.

Figure 4 - Structural biology of insulin and IGF1 receptors: implications for drug design

Figure 4

Strategies for drug discovery with a dimeric or dimerizing receptor tyrosine kinase.

Figure 5 - Structural biology of insulin and IGF1 receptors: implications for drug design

Figure 5

Ligand binding to the insulin and IGF1 receptors.

Table 1 - Structural biology of insulin and IGF1 receptors: implications for drug design

Table 1

Receptor crosslinking*