FIGURE 1 | Schematic representation of the concepts behind dynamic combinatorial chemistry and virtual combinatorial libraries.

From the following article:

Drug discovery by dynamic combinatorial libraries

Olof Ramström & Jean-Marie Lehn

Nature Reviews Drug Discovery 1, 26-36 (January 2002)

doi:10.1038/nrd704

Drug discovery by dynamic combinatorial libraries

Top: a true dynamic library of interchanging 'keys' (for example, ligands), which are formed through reversible exchange of a limited number of initial key building blocks. On addition of a molecular 'lock' (for example, a receptor), the best binder is selected, forcing the library to rearrange so as to produce more of this member. Bottom: generation of a virtual combinatorial library, the constituents of which become detectable only in the presence of the selector.

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