Top 10
The top ten charts the articles that have been downloaded most often, in HTML format, from the Nature Reviews Clinical Oncology website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.
Top of pageNews and Views
Hematology: The case against rituximab maintenance
Bruce D. Cheson
doi:10.1038/nrclinonc.2009.161
Research Highlight
Research Highlight
Pathology: Prostate cancer—personalized response prediction
Vessela Vassileva
doi:10.1038/nrclinonc.2009.156
Research Highlight
Medical oncology: T-cell infiltrate predicts long-term survival in CRC
Lisa Hutchinson
doi:10.1038/nrclinonc.2009.153
Research Highlight
Chemotherapy: Metastatic breast cancer—optimal front-line therapy
Vessela Vassileva
doi:10.1038/nrclinonc.2009.135
Review
An overview of small-molecule inhibitors of VEGFR signaling
S. Percy Ivy, Jeannette Y. Wick & Bennett M. Kaufman
doi:10.1038/nrclinonc.2009.130
The VEGFR small-molecule inhibitors of angiogenesis show promise for oncology patients. These rationally designed inhibitors are being tailored for use in specific malignancies and will have a pivotal role in personalized medicine. The authors discuss the potential of these agents for treating tumors such as metastatic renal-cell carcinoma, GIST and hepatocellular carcinoma.
Review
Src kinases as therapeutic targets for cancer
Lori C. Kim, Lanxi Song & Eric B. Haura
doi:10.1038/nrclinonc.2009.129
Src family kinases have been extensively studied and found to be central mediators in multiple signaling pathways that are important in oncogenesis. Preclinical studies have shown that SFK inhibitors can suppress tumor growth and metastases. The authors of this Review discuss the potential use of these agents to target cancer in humans.
Review
Myeloproliferative neoplasms: contemporary diagnosis using histology and genetics
Ayalew Tefferi, Radek Skoda & James W. Vardiman
doi:10.1038/nrclinonc.2009.149
This Review discusses the criteria for the diagnosis and classification of myeloproliferative neoplasms in relation to the revised 2008 WHO classification. The authors summarize the histology of these tumors in the context of the 2008 WHO classification system, discuss associated cytogenetic and molecular abnormalcies of myeloproliferative neoplasms, and provide diagnostic algorithms that are tailored for routine clinical use.
Review
Gene-expression profiling in epithelial ovarian cancer
Panagiotis A Konstantinopoulos, Dimitrios Spentzos & Stephen A Cannistra
doi:10.1038/ncponc1178
In epithelial ovarian cancer, gene-expression profiling has been used to provide prognostic information, to predict response to first-line platinum-based chemotherapy, and to discriminate between different histologic subtypes. The authors of this Review summarize the contributions of gene-expression profiling to the diagnosis and management of epithelial ovarian cancer and discuss ways in which this technique could become a useful tool in clinical management.
Review
Neurological adverse effects caused by cytotoxic and targeted therapies
David Schiff, Patrick Y. Wen & Martin J. van den Bent
doi:10.1038/nrclinonc.2009.128
With the development of new chemotherapy and targeted agents, neurotoxicity has become increasingly important as a cause of dose-limiting toxicity. The authors review the important and unusual neurotoxicities related to chemotherapy and targeted agents approved since January 1999.
