Primary HPV screening for cervical cancer prevention: results from European trials
Elsebeth Lynge
&
Matejka Rebolj
Published online: 10 November 2009 | doi:10.1038/nrclinonc.2009.167
Six European randomized controlled trials that will compare human papillomavirus (HPV) testing with cytology testing for cervical screening are under way. The outcome of HPV testing versus cytology testing depends not only on the relative accuracy of the primary test but also on how radical the different triage procedures are. Two trials have shown a 50% reduction in grade 3 cervical intraepithelial neoplasia detection in subsequent screening rounds. The authors critically discuss the reasons for the different results observed in these trials and the implications for primary screening.
Gamma-delta T-cell lymphomas
Claudio Tripodo,
Emilio Iannitto,
Ada Maria Florena,
Carlo Ennio Pucillo,
Pier Paolo Piccaluga,
Vito Franco
&
Stefano Aldo Pileri
Published online: 10 November 2009 | doi:10.1038/nrclinonc.2009.169
Gamma-delta lymphomas are rare and aggressive lymphomas with a poor prognosis. The authors of this Review discuss the clinical and biological features of the two types of such lymphomas and the diagnostic challenges associated with these still insufficiently known diseases.
Liver metastases from colorectal cancer: radioembolization with systemic therapy
Nils H. Nicolay,
David P. Berry
&
Ricky A. Sharma
Published online: 03 November 2009 | doi:10.1038/nrclinonc.2009.165
Most patients with advanced colorectal cancer die from hepatic metastases. Radioembolization is a technique for administering radiotherapy internally to unresectable primary or secondary hepatic malignancies in a single procedure to improve local control of disease. This technique enables significant downsizing of liver metastases to permit subsequent resection. The rationale for this approach combined with cytotoxic and molecularly targeted agents is discussed.
