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Gynecological cancer

More evidence supporting human papillomavirus testing

Clinical trials have consistently demonstrated the superior sensitivity of human papillomavirus (HPV) testing compared with cytology (Pap) testing for identifying women at risk of cervical cancer. Rijkaart et al. have now shown that adding HPV testing to routine cervical cancer screening can further reduce the risk of cervical cancer compared to Pap testing alone.

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Figure 1: Sensitivity versus positive predictive value for CIN3 or more severe diagnoses (CIN3+) for combinations of cytologic interpretation and HPV16 detection among HPV-positive women.

References

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Acknowledgements

The views expressed represent only those of the author and do represent the views of The American Society for Clinical Pathology.

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P. E. Castle declares that he serves as a member of a Data and Safety Monitor Board for HPV vaccines on behalf of Merck Sharp & Dohme. P. E. Castle has a non-disclosure agreement with Roche (Pleasanton, CA, USA) to analyze the results of a large clinical trial on HPV testing

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Castle, P. More evidence supporting human papillomavirus testing. Nat Rev Clin Oncol 9, 131–132 (2012). https://doi.org/10.1038/nrclinonc.2012.16

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