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Lumpectomy and partial breast irradiation for early-stage breast cancer following mantle irradiation for Hodgkin's lymphoma

Nature Clinical Practice Oncology volume 5, pages 426–429 (2008)Cite this article

Abstract

Background A 57-year-old woman who received treatment with mantle irradiation and systemic chemotherapy for Hodgkin's lymphoma diagnosed at the age of 42 underwent screening mammography, which revealed abnormal density at the upper outer quadrant of the left breast.

Investigations Left breast ultrasound and MRI, ultrasound-guided biopsy, immunohistochemistry, chest X-ray.

Diagnosis Stage T1bN0M0 left breast cancer.

Management Lumpectomy, sentinel lymph-node biopsy and fractionated partial breast irradiation using 3-dimensional conformal technique.

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Figure 1: Reconstructed dose–volume histogram of prior mantle radiotherapy.
Figure 2: Dose–volume histogram of partial breast irradiation.
Figure 3: Cosmetic results after lumpectomy and partial breast irradiation.

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Acknowledgements

This work was supported in part by the Jane Mailloux Research Fund, the Blanche Montesi Fund and the Tim Levy Fund for breast cancer research.

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Authors and Affiliations

  1. at the Department of Radiation Oncology, MA Alm El-Din is a Breast Oncology Fellow, JK Feng is a Senior Medical Dosimetrist, and AG Taghian is Chief of the Breast Oncology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.,

    Mohamed A Alm El-Din, Jennifer K Feng & Alphonse G Taghian

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  1. Mohamed A Alm El-Din
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  2. Jennifer K Feng
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  3. Alphonse G Taghian
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Correspondence to Alphonse G Taghian.

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The authors declare no competing financial interests.

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Alm El-Din, M., Feng, J. & Taghian, A. Lumpectomy and partial breast irradiation for early-stage breast cancer following mantle irradiation for Hodgkin's lymphoma. Nat Rev Clin Oncol 5, 426–429 (2008). https://doi.org/10.1038/ncponc1135

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