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The incidence of skin cancer as a result of exposure to ultraviolet radiation, either through sunlight or artificial tanning facilities, is increasing. In this Viewpoint the authors discuss the risks of melanoma for adolescents using artificial tanning facilities and call on authorities to restrict access to such facilities.
Angiogenesis is a complex, highly regulated process that is crucial for tumor growth and metastasis. Insights into the molecular mechanisms of tumor angiogenesis have led to the identification of potential angiogenic targets and the development of novel antivascular agents. This Review highlights the results of the latest clinical studies of antivascular agents in ovarian cancer and discusses the challenges and opportunities for future clinical trials.
Metastasis remains the major driver of mortality in patients with cancer. The similarities and differences between primary tumors and metastases are described, and pathways controlling the colonization of a distant organ and incorporation of anti-metastatic therapies into clinical testing are discussed. The authors emphasize that the time is ripe for metastasis and metastatic colonization to enter mainstream clinical development and testing.
Preclinical and clinical data indicate a number of potential roles of diffusion-weighted MRI in the characterization of malignancy such as determination of lesion aggressiveness and monitoring response to therapy. This Review outlines the biological basis of observations made using this technique and the authors discuss the strength of evidence for adoption of DW-MRI as a biomarker for the assessment of tumor response.
Methotrexate-associated lymphoproliferative disorders are rare conditions mostly observed in patients receiving immunosuppression therapy. Tran and coauthors report the first documented case of methotrexate-associated mantle-cell lymphoma in a 75-year-old patient with myasthenia gravis. After cessation of methotrexate, the patient was treated with anthracycline-based combination chemoimmunotherapy and maintenance rituximab therapy and achieved complete remission. The authors discuss the management options for patients with methotrexate-associated mantle-cell lymphoma.
