Table of contents
August 2007 Volume 4 No 8
Viewpoints
CT screening for lung cancer is justified
440The evidence for use of spiral CT for lung cancer screening and the results and implications of the International Early Lung Cancer Action Program study are discussed in this Viewpoint.
doi:10.1038/ncponc0852 | Full Text | PDF (125K)
Screening for lung cancer with spiral CT is not justified
442There are a number of factors that make cancer screening more difficult in the lungs than in other organs. These factors include the characteristics of the patient group being screened, the heterogeneous nature of lung cancer and issues with the screening process itself, as discussed in this Viewpoint.
doi:10.1038/ncponc0878 | Full Text | PDF (125K)
Research Highlights
p53 and hMSH2 mutations correlate with a poor prognosis in patients with HCC
444EHF audiometry and DPOAEs reveal early ototoxicity of platinum chemotherapy
444Nodal status after neoadjuvant therapy predicts survival in esophageal cancer
444doi:10.1038/ncponc0862 | Full Text | PDF (103K)
Ki-67 expression is associated with poor prognosis in early-stage breast cancer
445Efficacy of escalated-dose conformal radiotherapy for prostate cancer control
445doi:10.1038/ncponc0864 | Full Text | PDF (103K)
KRAS mutation predicts response to cetuximab and chemotherapy in mCRC
446Tyrosinase status has definite prognostic value in patients with metastatic melanoma
446doi:10.1038/ncponc0866 | Full Text | PDF (102K)
Collagen XXIII—a promising biomarker for prostate cancer metastasis
447Increased risk of cancer in hyperthyroid patients treated with radioactive iodine
447Widespread immunization of young women could reduce the burden of HPV-related disease
447doi:10.1038/ncponc0869 | Full Text | PDF (100K)
Good survival after radical oophorectomy for ovarian metastasis
448doi:10.1038/ncponc0870 | Full Text | PDF (101K)
p95HER2-overexpressing breast tumors have a poor response to trastuzumab
449Radiation therapy for breast cancer increases the risk of secondary malignancy
449Sonoelastography can diagnose cervical lymph-node metastasis with high accuracy
450Daily use of aspirin might be associated with modestly reduced overall cancer incidence
450HLA-matched allo-transplantation is beneficial for younger patients with AML
450Practice Points
Antioxidant vitamin supplementation and control of gastric cancer
452doi:10.1038/ncponc0853 | Full Text | PDF (130K)
Angiogenesis inhibition: the next frontier in multimodal therapy for glioblastoma multiforme
454doi:10.1038/ncponc0879 | Full Text | PDF (137K)
What are the indications for sorafenib treatment in patients with renal cell carcinoma?
456doi:10.1038/ncponc0880 | Full Text | PDF (138K)
Sunitinib—a new standard of care for metastatic renal cell carcinoma
458doi:10.1038/ncponc0882 | Full Text | PDF (139K)
Should gemcitabine be used as adjuvant chemotherapy in patients with resectable pancreatic cancer?
460doi:10.1038/ncponc0884 | Full Text | PDF (136K)
Reviews
Management of nonmelanoma skin cancer in 2007
462Surgery is the most frequently used approach in the treatment of nonmelanoma skin cancer, and Mohs micrographic surgery, conventional excision, cryosurgery, or electrodesiccation and curettage are usually performed. Newer noninvasive options include topical chemotherapeutics, biological immune-response modifiers, retinoids, and photodynamic therapy. Neville et al. propose that treatments should be tailored to the tumor type, location, size, and histological pattern, and suggest that, although surgical methods remain the most frequently used, newer noninvasive treatments can be used in select tumors and may reduce morbidity.
doi:10.1038/ncponc0883 | Full Text | PDF (836K)
Drug Insight: advances in renal cell carcinoma and the role of targeted therapies
470There have been considerable advances in our understanding of renal cell carcinoma, which have been translated into the development of several drugs with proven efficacy, with kinase inhibitors demonstrating significant activity. The authors of this review discuss the targeted agents that have proved efficacious in the difficult-to-treat metastatic setting, and highlight the issues of patient selection, scheduling, dose, duration of treatment, potential combinations and toxicity.
doi:10.1038/ncponc0901 | Full Text | PDF (319K)
Technology Insight: confocal laser endoscopy for in vivo diagnosis of colorectal cancer
480Confocal laser endomicroscopy is a new endoscopic tool that allows in vivo histology at subcellular resolution during ongoing endoscopy, and permits subsurface imaging of normal and neoplastic human mucosa. The authors of this Review highlight why confocal laser endomicroscopy can no longer be regarded as just another endoscopic technique but emerges as a crucial novel imaging technique for in vivo diagnosis of colorectal cancer.
doi:10.1038/ncponc0881 | Full Text | PDF (1,501K)
Case Study
Gemtuzumab therapy for isolated extramedullary AML relapse following allogeneic stem-cell transplant
491Isolated extramedullary relapse of acute myeloid leukemia after allogeneic transplantation is a rare phenomenon, which is not well understood. Owonikoko et al. describe the case of a patient with primary refractory acute myeloid leukemia who received chemotherapy treatment on protocol, salvage therapy, matched-unrelated-donor stem-cell transplants and donor-lymphocyte infusion. The patient received radiation therapy and gemtuzumab to treat numerous extramedullary sites of disease and remains disease free with no further cytotoxic therapy since gemtuzumab administration. The authors highlight the safety and efficacy of gemtuzumab in the treatment of patients with isolated extramedullary relapse.
doi:10.1038/ncponc0899 | Full Text | PDF (347K)
