FIGURE 3  Tumor responses following incidental viral infection, vaccination or treatment with non-engineered virus strains.

From the following article:

Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress

Ta-Chiang Liu, Evanthia Galanis and David Kirn

Nature Clinical Practice Oncology (2007) 4, 101-117
doi:10.1038/ncponc0736

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Figure 3.  Tumor responses following incidental viral infection, vaccination or treatment with non-engineered virus strains.

(A) Complete regression of Burkitt's lymphoma (white arrow) over 2 weeks in a patient experiencing acute measles infection. Permission obtained from Elsevier © Bluming AZ and Ziegler JL (1971) Lancet 2: 105–106.4 (B) Complete hematologic response of chronic lymphocytic leukemia following patient vaccination with vaccinia and subsequent virus dissemination. Permission obtained from American Medical Association © Hansen RM and Libnoch JA (1978) Arch Intern Med 138: 1137–1138.8 (C) Major M-spike response in patient with multiple myeloma during chronic intravenous therapy with attenuated vaccinia strain AS. Reproduced from Kawa A and Arakawa S (1987) Jpn J Exp Med 57: 79–81.20 Abbreviations: IgA, immunoglobulin A; NK, natural killer cells; PE, plasma exchange.

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