TABLE 2 The evolution of microarrays for gene-expression analysis over the years.6
From the following article:
Technology Insight: tuning into the genetic orchestra using microarrays—limitations of DNA microarrays in clinical practice
Ambreen Abdullah-Sayani, Jolien M Bueno-de-Mesquita and Marc J van de Vijver
BACK TO ARTICLE| Type of array | Number of array spots | Target | Manufacturer | Year introduced | Usage |
|---|---|---|---|---|---|
aAlthough nylon membranes provide some advantages, such as flexibility, low cost and possibility of striping and rehybridizations, their use has almost disappeared. Abbreviations: cDNA, complementary DNA; NA, not applicable. | |||||
| Nylon/nitrocellulose—cDNAa | 500–5,000 | cDNA clones | NA | 1996 | Almost out of use |
| Glass—cDNA | 50–40,000 | cDNA clones | NA | 1996 | Rapidly decreasing |
| Glass/quartz—oligonucleotide | 6,000 | 20mer oligonucleotides | Affymetrix | 1998 | Almost out of use |
| 22,000–45,000 | 25mer oligonucleotides | Affymetrix | 2000–2001 | Increasing | |
| 22,000–44,000 | 60mer oligonucleotides | Agilent | 2004 | Increasing | |
| Exon array | 1 million exons | 123mer oligonucleotides (median) | Affymetrix | 2005 | Increasing |
| BeadArray | 50,000 | 50mer oligonucleotides | Illumina | 2005 | Increasing |
