FIGURE 3  Response to gefitinib in extensive leptomeningeal carcinomatosis

From the following article:

Gefitinib response of erlotinib-refractory lung cancer involving meninges—role of EGFR mutation

Nicholas W Choong, Sascha Dietrich, Tanguy Y Seiwert, Maria S Tretiakova, Vidya Nallasura, Gareth C Davies, Stanley Lipkowitz, Aliya N Husain, Ravi Salgia and Patrick C Ma

Nature Clinical Practice Oncology (2006) 3, 50-57
doi:10.1038/ncponc0400

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Figure 3.  Response to gefitinib in extensive leptomeningeal carcinomatosis

MRI scan of the lower thoracic and lumbar spine (A,B) prior to starting gefitinib, and (C,D) 2 months after gefitinib monotherapy, demonstrating a dramatic reduction in the number and enhancement of leptomeningeal metastases (solid white arrows), correlating with the positive clinical response.

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