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Nature Reviews Clinical Oncology 2, 70–71 (1 February 2005) | doi:10.1038/ncponc0076

Can docetaxel plus estramustine prolong survival of men with metastatic hormone-refractory prostate cancer?

Stefan Sleijfer & Gerrit Stoter

Petrylak DP et al. (2004) Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 351: 1513–1520 Synopsis Background Mitoxantrone (Novantrone, OSI) plus corticosteroids relieves pain, but does not prolong survival, of men with metastatic androgen-independent prostate cancer.