FIGURE 1 Effects of DNA methylation and chromatin structure on gene transcription in normal and tumor cells
From the following article:
Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies
Steven D Gore
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Figure 1. Effects of DNA methylation and chromatin structure on gene transcription in normal and tumor cells
Ac, acetyl; DNMT, DNA methyltransferase; H(3, 4), histone (3, 4); HDAC, histone deacetylase; MBD, MeCP2, methyl-CpG binding proteins; MTase, methyltransferase; TRD, transcriptional repression domain; TSA, trichostatin A; VPA, valproic acid. Reprinted with permission from Leone G et al. (2003) Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS. Clinical Immunology 109: 89–102. © (2003) Elsevier.
