An analysis from The Cancer Genome Atlas (TCGA) network has revealed the genomic landscape of pancreatic ductal adenocarcinoma (PDAC). An integrated genomic, transcriptomic and proteomic analysis revealed recurrent somatic mutations in a wide range of genes, including TP53, CDKN2A and PBRM1. Mutations in KRAS were observed in 93% of samples. Furthermore, considerable heterogeneity in oncogenic KRAS mutations was observed, including the presence of biallelic KRAS mutations and the identification of multiple KRAS mutations in the same individual cell. These findings confirm the biological complexity of PDAC.