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Clinical trials

Subgroup analyses in randomized trials—more rigour needed

Nature Reviews Clinical Oncology volume 12, pages 506–507 (2015)Cite this article

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An analysis of reports from phase III trials (published between 2011 and 2013) investigating patients with solid tumours found widespread failings in both the conduct and reporting of subgroup analyses. Readers might well be misled by such analyses. Editors should, therefore, implement policies to reduce the risk of publishing misleading results.

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Authors and Affiliations

  1. Nuffield Department of Orthopaedics, Centre for Statistics in Medicine, Rheumatology & Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK

    Douglas G. Altman

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  1. Douglas G. Altman
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Correspondence to Douglas G. Altman.

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The author declares no competing financial interests.

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Altman, D. Subgroup analyses in randomized trials—more rigour needed. Nat Rev Clin Oncol 12, 506–507 (2015). https://doi.org/10.1038/nrclinonc.2015.133

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