Findings from whole-genome, whole-exome and/or transcriptome sequencing of 37 paediatric adrenocortical tumours have demonstrated the prognostic importance of specific mutations. 100% of tumours had IGF2 overexpression, and the majority (78%) had TP53 mutations. The presence of concomitant mutations was found to be predictive of clinical outcome; in particular, the presence of concomitant somatic ATRX and germline TP53 mutations was associated with significantly worse event-free survival and higher disease stage.
References
Pinto, E. M. et al. Genomic landscape of paediatric adrenocortical tumours. Nat. Commun. 10.1038/ncomms7302
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Adrenocortical cancer mutations are prognostic for survival. Nat Rev Clin Oncol 12, 312 (2015). https://doi.org/10.1038/nrclinonc.2015.59
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DOI: https://doi.org/10.1038/nrclinonc.2015.59
