Presenting at ECC 2015, Catherine Pietanza outlined data indicating that a delta-like ligand 3 (DLL3)-directed antibody–drug conjugate, rovalpituzumab tesirine (Rova-T), promises to become the first targeted agent for small-cell lung cancer (SCLC)—a disease with a dismal prognosis. In a phase I trial, 73 patients received Rova-T in the second-line or third-line (no agents are approved in the latter setting). The frequency of DLL3 expression was high (>70%), and among 27 DLL3+ patients treated in the expansion cohorts, 44% had a partial response and 34% stable disease. Importantly, in the third-line setting, the response rate was 45% in the DLL3+ patients. Ongoing reponses approaching 1 year have been observed in some patients, which is remarkable.
References
Pietanza, C. et al. Safety, activity, and response durability assessment of single agent rovalpituzumab tesirine, a delta-like protein3 (DLL3)-targeted anibody drug conjugate (ADC), in small cell lung cancer (SCLC) [abstract LBA 7]. Presented at the ECC 2015
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Novelty of Rova-T—first targeted agent for SCLC. Nat Rev Clin Oncol 12, 684 (2015). https://doi.org/10.1038/nrclinonc.2015.183
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DOI: https://doi.org/10.1038/nrclinonc.2015.183