Nature Reviews Clinical Oncology

Volume 14, No 9 September 2017



Click here to find out what's on the clinical oncology conference circuit and which meetings will be attended by Nature Reviews Clinical Oncology.

Front cover of the current issue of Nature Reviews Clinical Oncology

2016 2-year Impact Factor 20.693 Journal Metrics 2-year Median 12

Current Issue

Featured article

Integrating liquid biopsies into the management of cancer

Giulia Siravegna, Silvia Marsoni, Salvatore Siena & Alberto Bardelli

Analysis of circulating tumour components using liquid biopsy approaches holds considerable promise to improve the detection and treatment of cancer. In this Review, Alberto Bardelli and colleagues outline how different forms of liquid biopsy, and particularly the assessment of circulating tumour DNA, can be exploited to guide patient care, and discuss the progress made to date in integrating such analyses into the clinic.

Current Issue

Featured article

Unravelling the biology of SCLC: implications for therapy

Joshua K. Sabari, Benjamin H. Lok, James H. Laird, John T. Poirier & Charles M. Rudin

For three decades, the treatment of small-cell lung cancer (SCLC) has remained essentially unchanged, and patient outcomes remain dismal. In the past 5 years, however, advances in our understanding of the disease, at the molecular level, have resulted in the development of new therapeutic strategies, encompassing immunotherapies and novel molecularly targeted agents. Herein, authors review the breakthroughs that hold the promise to improve SCLC outcomes.

Advance online publication


The immune contexture in cancer prognosis and treatment

Wolf H. Fridman, Laurence Zitvogel, Catherine Sautès–Fridman & Guido Kroemer

Virtually all successful treatments of cancer either create, restore or enhance the antitumour immune response. Therefore, the specific features of the immune microenvironment, both before and after treatment, are important determinants of patients' outcomes. In this Review, the authors describe the influence of the immunological characteristics of the tumour microenvironment on responses to treatment in patients with a variety of cancers.

Society News


The European School of Oncology (ESO) in partnership with Nature Reviews Clinical Oncology is pleased to announce an e-ESO session on "Highlights of the Advanced Prostate Cancer Consensus Conference (APCCC) 2017". This topic will be discussed by Aurelius Omlin during a live webcast on Thursday 7th September 17:15–18:00 UK time. Online participants will be able to submit questions.

Visit to download the ESO app for iPhones, iPads and Android devices.


Web collection on Cancer genomics – from bench to bedside

The advent of massively parallel sequencing technologies has driven the analysis of cancer genomes at an unprecedented resolution. This collection provides a comprehensive bench-to-bedside overview of cancer genomics.


The world of medicine is fast-paced and ever-changing; the Key Advances in Medicine eBook is bursting with information for medical students, physicians and clinical researchers wishing to keep up with the most significant medical breakthroughs of the past year.
This eBook, which is free to download for registered users, contains 46 articles summarizing the key clinical studies published in 2014 and highlighting the trends to watch out for in 2015. The articles are written by international experts who identify the top ground-breaking research papers within their speciality. Between them, the authors summarise more than 180 key papers from journals such as The New England Journal of Medicine and The Lancet, across eight medical specialities.
Key Advances in Medicine, a product from the clinical Nature Reviews journals, is a vital resource for anyone interested in the most relevant biomedical and clinical developments of 2014.

A decade in medicine eBook

The past 10 years has seen great advances in the understanding and treatment of human disease. For expert perspectives on the most important breakthroughs, don't miss the A Decade in Medicine eBook. In this special collection of 47 articles—commissioned to celebrate the 10th anniversary of the launch of the clinical Nature Reviews journals—leading experts highlight the most important advances in eight medical specialties between 2004 and 2015, and comment on future developments in their fields. The A Decade in Medicine eBook is FREE to download for registered users.

About the cover

MUSE (microscopy with UV surface excitation) image of fixed, unsectioned breast tissue showing a partially opened duct surrounded by stromal collagen and elastin. Cover image supplied by Richard Levenson, Department of Pathology and Laboratory Medicine, University of California Davis Medical Center at Sacramento, California, USA.

POSTER on Breast cancer

Breast cancer consists of many diseases that can be subdivided into different intrinsic subtypes according to genetic profiles, and this information is rapidly changing treatment decisions and personalized medicine. The latest developments in our genetic understanding of the intrinsic subtypes of breast cancer are highlighted in this poster, which is produced with support from NanoString® Technologies, Inc.

Focus issue on paediatric cancer

In the West, childhood cancers are associated with a very high level of treatment success, with many childhood survivors reaching adulthood. Nevertheless, progress in the field of paediatric oncology has lagged behind that of adult malignancies. Treating children with cancer brings into play a number of issues not typically experienced with adult patients, such as performing surgery near growing structures. This focus issue aims to look at a number of the key issues, and the cutting-edge research, surrounding treating arguably our most vulnerable patients.

Focus issue on 10th anniversary

November 2014 marks the 10th anniversary of Nature Reviews Clinical Oncology. To celebrate this milestone, we have commissioned a collection of articles to summarize the major advances in clinical oncology over the past decade. These articles, together with a special infographic, provide an authoritative snapshot of clinical oncology in 2014, and how the field might progress over the next 10 years.

Focus issue on prostate cancer

Don't miss our recent Focus issue on prostate cancer, which covers low-risk disease, management of high-risk disease, multiparametric MRI for detection, staging and treatment planning, considerations for treating elderly men with prostate cancer, and more...

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Nature Reviews Clinical Oncology was previously published as Nature Clinical Practice Oncology.


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