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  • In patients with carotid artery disease, the presence of microplastics and nanoplastics in the carotid plaque is associated with an increased risk of death or major cardiovascular events compared with patients in whom microplastics and nanoplastics were not detected.

    • Karina Huynh
    Research Highlight
  • Protein glycosylation is vital to the regulation of cell function, and changes in this post-translational modification underlie many disease processes. In this Review, Chatham and Patel discuss how protein glycosylation contributes to normal cardiovascular function and its role in cardiovascular disease, identifying important knowledge gaps and areas for future research.

    • John C. Chatham
    • Rakesh P. Patel
    Review Article
  • Non-coding RNAs are implicated in the pathophysiology of ischaemic heart disease and heart failure. In this Review, Caporali and colleagues examine the biology of these molecules and discuss the potential of non-coding RNAs for translation to the clinic as biomarkers and therapeutics in adverse cardiac remodelling leading to ischaemic heart failure.

    • Andrea Caporali
    • Maryam Anwar
    • Costanza Emanueli
    Review Article
  • In this Tools of the Trade article, Charrière describes the FluoStep FRET-based biosensor used for high-resolution imaging of cAMP nanodomains that are involved in intracellular signalling in cardiomyocytes.

    • Camille Charrière
    Tools of the Trade
  • Novel cardiovascular therapeutics have the potential to improve health outcomes, but financial toxicity from high out-of-pocket costs can limit the reach of these medications and worsen existing health disparities. Understanding the phenomenon of financial toxicity in treating cardiovascular disease is crucial to achieving health equity.

    • Alexander H. Gunn
    • Akshay Pendyal
    Comment
  • In this Tools of the Trade article, Olivera describes a rat model of pre-elampsia that has been instrumental for investigating potential long-term cardiovascular effects in offspring.

    • Sol Olivera
    • Delyth Graham
    Tools of the Trade
  • Shoaran and Maffia recount how our understanding of the role of inflammation in atherosclerosis has evolved and highlight the study by Göran Hansson and colleagues that provided the first hint of the involvement of the adaptive immune response in atherosclerosis.

    • Mohsen Shoaran
    • Pasquale Maffia
    Journal Club
  • In this Review, Lam and colleagues evaluate the current literature on sex-related differences in treatment responses in patients with heart failure and highlight potential approaches for tailored therapies and the need for sex-specific evaluation of treatment efficacy and safety in future research.

    • Janice Y. Chyou
    • Hailun Qin
    • Carolyn S. P. Lam
    Review Article
  • Rebecca Gilchrist discusses the study that demonstrated the long-term modulation of ventricular repolarization by the sequence of electrical activation in the human heart and established the concept of cardiac memory.

    • Rebecca J. Gilchrist
    Journal Club
  • Atrial fibrillation is the most common sustained arrhythmia and imposes a substantial burden on patients and health-care providers. Clinical evidence suggests that antiarrhythmic therapy to restore and maintain sinus rhythm (rhythm control) can reduce adverse cardiovascular outcomes in patients with new-onset atrial fibrillation. As a result, a paradigm shift towards rhythm control over rate control therapy is emerging, increasing the clinical need for effective and safe antiarrhythmic drugs.

    • Felix Wiedmann
    • Constanze Schmidt
    Clinical Outlook
  • Using a porcine model of cardiogenic shock, Lamberti and colleagues develop a clinically accessible, patient-validated metric to assess pulmonary vascular compliance that can predict tolerance to left-sided ventricular assist device support.

    • Karina Huynh
    Research Highlight
  • A study shows that congenital heart defects in Down syndrome are in part caused by increased dosage of the DYRK1A gene, which lies on chromosome 21, leading to reduced proliferation and mitochondrial dysfunction in cardiomyocytes.

    • Irene Fernández-Ruiz
    Research Highlight
  • In this Review, Lakhal-Littleton and Cleland use the latest understanding of iron homeostasis to evaluate existing and emerging markers of iron status, describe the reciprocal relationship between iron status and heart failure, and mechanistically examine the benefits of oral and intravenous iron replacement therapies.

    • Samira Lakhal-Littleton
    • John G. F. Cleland
    Review Article
  • In this Comment, we critically examine the association between the increasing consumption of ultra-processed foods and their negative effect on cardiovascular health. We explore the historical evolution of food processing, the Nova food classification and the epidemiological evidence, and highlight the need for urgent public health interventions.

    • Fernanda Rauber
    • Renata Bertazzi Levy
    Comment