Although the majority of implanted valves used in aortic valve surgery are tissue valves (bioprostheses), the mechanisms by which they interact with the host are not well understood. A new study by Flameng et al. gives insight into the structural and functional changes that result from patient–bioprosthesis mismatch.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Yacoub, M. H., Kilner, P. J., Birks, E. J. & Misfeld, M. The aortic outflow and root: a tale of dynamism and crosstalk. Ann. Thorac. Surg. 68 (Suppl. 3), S37–S43 (1999).
Yacoub, M. H. & Takkenberg, J. J. Will heart valve tissue engineering change the world? Nat. Clin. Pract. Cardiovasc. Med. 2, 60–61 (2005).
Flameng, W. et al. Prosthesis-patient mismatch predicts structural valve degeneration in bioprosthetic heart valves. Circulation 121, 2123–2129 (2010).
Hahn, C. & Schwartz, M. A. Mechanotransduction in vascular physiology and atherogenesis. Nat. Rev. Mol. Cell Biol. 10, 53–62 (2009).
O'Brien, K. D. Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more). Arterioscler. Thromb. Vasc. Biol. 26, 1721–1728 (2006).
Shetty, R. et al. Lipid-mediated inflammation and degeneration of bioprosthetic heart valves. Eur. J. Clin. Invest. 39, 471–480 (2009).
Melina, G. et al. Three-dimensional in vivo characterization of calcification in native valves and in Freestyle versus homograft aortic valves. J. Thorac. Cardiovasc. Surg. 130, 41–47 (2005).
Schoen, F. J. & Levy, R. J. Calcification of tissue heart valve substitutes: progress toward understanding and prevention. Ann. Thorac. Surg. 79, 1072–1080 (2005).
Mohammadi, S., Baillot, R., Voisine, P., Mathieu, P. & Dagenais, F. Structural deterioration of the Freestyle aortic valve: mode of presentation and mechanisms. J. Thorac. Cardiovasc. Surg. 132, 401–406 (2006).
El-Hamamsy, I. et al. Long-term outcomes following autograft versus homograft aortic root replacement in adults—a prospective randomized trial. Lancet (in press).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Yacoub, M., El-Hamamsy, I. The private life of tissue valves. Nat Rev Cardiol 7, 424–426 (2010). https://doi.org/10.1038/nrcardio.2010.98
Issue Date:
DOI: https://doi.org/10.1038/nrcardio.2010.98
