Review
Nature Reviews Cardiology 6, 543-552 (August 2009) | doi:10.1038/nrcardio.2009.102
Subject Categories: Disease markers | Vascular disease
Biomarkers of abdominal aortic aneurysm progression. Part 2: inflammation
Femke A. M. V. I. Hellenthal1, Willem A. Buurman1, Will K. W. H. Wodzig1 & Geert Willem H. Schurink1 About the authors
Abstract
Defining progression of abdominal aortic aneurysm (AAA) is complicated by several factors, including measurement error, duration of follow-up, and the imaging modality used to assess AAA expansion. Investigations of biomarkers of AAA progression should be standardized so that valid comparisons can be made. Previous research has shown some promising advances towards identifying a reliable and individual predictor of AAA progression. In this second part of our Review on biomarkers of AAA progression, we examine direct and indirect markers of inflammation including various cytokines, C-reactive protein, activators of tissue plasminogen activator and urokinase plasminogen activator, and osteopontin.
Author affiliations
- Maastricht University Medical Center, Maastricht, The Netherlands.
Correspondence to: F. A. M. V. I. Hellenthal, Department of General Surgery, Maastricht University Hospital, P. Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Email: f.hellenthal@mumc.nl
Published online 23 June 2009
