Drug-eluting stent pathology—should we still be cautious?

Gaku Nakazawa, Aloke V Finn and Renu Virmani

doi:10.1038/ncpcardio1093 | Full Text | PDF (104K)

The role of salt in hypertension: the complexity seems to become clearer

Edward D Frohlich

In this Viewpoint, Edward Frohlich provides an update to his Review from 2004 and posits that the role of salt in hypertension is far more complex than thought previously—that it 'simply' raises arterial pressure.

doi:10.1038/ncpcardio1087 | Full Text | PDF (121K)

Statin therapy discontinuation increases risk of death in survivors of ischemic stroke

doi:10.1038/ncpcardio1041 | Full Text | PDF (89K)

Encouraging increase in the use of medical therapy in patients hospitalized with AMI

doi:10.1038/ncpcardio1042 | Full Text | PDF (89K)

Value of self-reported medication adherence in patients with coronary heart disease

doi:10.1038/ncpcardio1043 | Full Text | PDF (100K)

Air pollution promotes ischemia and inhibits fibrinolytic function in patients with CHD

doi:10.1038/ncpcardio1047 | Full Text | PDF (89K)

Fluctuations in triglyceride levels could help to predict CHD risk in young adults

doi:10.1038/ncpcardio1048 | Full Text | PDF (100K)

Study identifies risk factors associated with infection after device implantation

doi:10.1038/ncpcardio1049 | Full Text | PDF (90K)

Outcomes of revascularization with MECC similar to those with off-pump CABG surgery

doi:10.1038/ncpcardio1050 | Full Text | PDF (100K)

Survival of heart transplantation candidates is improving

doi:10.1038/ncpcardio1051 | Full Text | PDF (87K)

Why do dialysis patients with AMI have such poor outcomes?

doi:10.1038/ncpcardio1052 | Full Text | PDF (87K)

Novel wireless technology reduces door-to-intervention time in STEMI

doi:10.1038/ncpcardio1053 | Full Text | PDF (97K)

Diabetes and CVD: impact of antidiabetic agents on morbidity and mortality

doi:10.1038/ncpcardio1046 | Full Text | PDF (96K)

Pediatric metabolic syndrome predicts CVD in later life

doi:10.1038/ncpendmet0659 | Full Text | PDF (87K)

OPTIMIZE-ing treatment for patients with heart failure

Todd M Koelling and Kim A Eagle

doi:10.1038/ncpcardio1037 | Full Text | PDF (179K)

Outpatient venous thromboembolism: the importance of optimum prophylaxis

Samuel Z Goldhaber

doi:10.1038/ncpcardio1036 | Full Text | PDF (131K)

How can the bleeding risk associated with warfarin therapy be reduced?

Freek WA Verheugt

doi:10.1038/ncpcardio1034 | Full Text | PDF (129K)

Does trimetazidine prevent myocardial injury after percutaneous coronary intervention?

Mario Marzilli

doi:10.1038/ncpcardio1013 | Full Text | PDF (127K)

Is it time to discard the apo B:apo A-I ratio as a predictor of cardiovascular disease?

Justo Sierra-Johnson and Rachel M Fisher

doi:10.1038/ncpcardio1040 | Full Text | PDF (128K)

Do preoperative anemia and polycythemia affect clinical outcome in patients undergoing major surgery?

Aryeh Shander and Lawrence Tim Goodnough

doi:10.1038/ncpcardio1033 | Full Text | PDF (132K)

Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning

Alexander R Lyon, Paul SC Rees, Sanjay Prasad, Philip A Poole-Wilson and Sian E Harding

Despite being an increasingly recognized clinical syndrome, the mechanism of stress or 'Takotsubo' cardiomyopathy remains unknown. In this thought-provoking Review, Lyon et al. present their novel hypothesis for the mechanism behind stress cardiomyopathy, and examine what implications this hypothetical pathophysiology could have for the use of drugs or devices in the treatment of patients with this syndrome.

doi:10.1038/ncpcardio1066 | Full Text | PDF (300K)

Statins and polyunsaturated fatty acids for treatment of atrial fibrillation

Irina Savelieva and John Camm

Rapidly developing experimental work has provided new insights into atrial fibrillation pathophysiology that will lead to new mechanism-based therapies. Statins and omega-3 polyunsaturated fatty acids have shown antiarrhythmic potential, exceeding any effect related to the treatment of underlying heart disease. Here Irina Savelieva and John Camm provide a contemporary evidence-based insight into how these agents could be exploited to prevent or reverse atrial remodeling in patients with atrial fibrillation.

doi:10.1038/ncpcardio1038 | Full Text | PDF (284K)

Late medical versus interventional therapy for stable ST-segment elevation myocardial infarction

Sammy Elmariah, Sidney C Smith Jr and Valentin Fuster

In light of recent studies demonstrating a lack of benefit with late reperfusion, Sammy Elmariah, Sidney Smith and Valentin Fuster review the data for and against late reperfusion for ST-segment elevation myocardial infarction. The effects of current medical therapies, risk-stratification techniques and indications for the use of late reperfusion over medical management are also examined.

doi:10.1038/ncpcardio1056 | Full Text | PDF (257K)

Pheochromocytoma: cyclic attacks of hypertension alternating with hypotension

Sergio L Kobal, Esther Paran, Aamer Jamali, Solly Mizrahi, Robert J Siegel and Jonathan Leor

Pheochromocytomas are catecholamine-producing tumors situated in the adrenal medulla. In this month's Case Study, Kobal and colleagues describe an unusual presentation of pheochromocytoma: cyclic waves of hypertension alternating with hypotension. The patient was successfully treated with phentolamine, intravenous fluids and doxazosin, before eventually undergoing surgical removal of the tumor.

doi:10.1038/ncpcardio1054 | Full Text | PDF (245K)