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  • Case Study
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Percutaneous closure of a patent foramen ovale in left-sided carcinoid heart disease

Abstract

Background A 51-year-old woman with a 5-year history of metastatic small bowel carcinoid disease developed fatigue and gradually worsening dyspnea on exertion, over 6 months.

Investigations Physical examination, transthoracic and transesophageal echocardiography, and aortography.

Diagnosis Left-sided carcinoid disease associated with a patent foramen ovale.

Management Percutaneous transcatheter closure of the patent foramen ovale.

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Figure 1: Systolic transesophageal echocardiograms of the patient at presentation
Figure 2: Aortogram during percutaneous closure of the PFO

References

  1. Modlin IM et al. (2003) A 5-decade analysis of 13,715 carcinoid tumors. Cancer 97: 934–959

    Article  Google Scholar 

  2. Anderson AS et al. (1997) Cardiovascular complications of malignant carcinoid disease. Am Heart J 134: 693–702

    Article  CAS  Google Scholar 

  3. Connolly HM and Pellikka PA (2006) Carcinoid heart disease. Curr Cardiol Rep 8: 96–101

    Article  Google Scholar 

  4. Connolly H et al (2001) Surgical management of left-sided carcinoid heart disease. Circulation 104 (Suppl): I36–I40

    Article  CAS  Google Scholar 

  5. Westberg G et al. (2001) Prediction of prognosis by echocardiography in patients with midgut carcinoid syndrome. Br J Surg 88: 865–872

    Article  CAS  Google Scholar 

  6. Roberts WC (1997) A unique heart disease associated with a unique cancer: carcinoid heart disease. Am J Cardiol 80: 251–256

    Article  CAS  Google Scholar 

  7. Pellikka PA et al. (1993) Carcinoid heart disease: clinical and echocardiographic spectrum in 74 patients. Circulation 87: 1188–1196

    Article  CAS  Google Scholar 

  8. Mansencal N et al. (2006) Assessment of patent foramen ovale in carcinoid heart disease. Am Heart J 151: 1129.e1–6

    Article  Google Scholar 

  9. Adler E et al (2007) Correlation or causation: untangling the relationship between patent foramen ovale and migraine. Curr Cardiol Rep 9: 7–12

    Article  Google Scholar 

  10. Moller JE et al. (2003) Factors associated with progression of carcinoid heart disease. N Engl J Med 348: 1005–1015

    Article  Google Scholar 

  11. Moller JE et al. (2005) Prognosis of carcinoid heart disease: analysis of 200 cases over two decades. Circulation 112: 3320–3327

    Article  Google Scholar 

  12. Butera G et al. (2006) Percutaneous versus surgical closure of secundum atrial septal defect: comparison of early results and complications. Am Heart J 151: 228–234

    Article  Google Scholar 

  13. Marenco J et al. (2000) Nonsurgical closure of a patent foramen ovale in a patient with carcinoid heart disease and severe hypoxia from interatrial shunting. Catheter Cardiovasc Interv 51: 210–213

    Article  CAS  Google Scholar 

  14. Mottram PM et al. (2006) Profound hypoxaemia corrected by PFO closure device in carcinoid heart disease. Eur J Echocardiogr [doi: 10.1016/j.euje.2006.08.003]

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Correspondence to Eric Adler.

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The authors declare no competing financial interests.

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Chaudhari, P., Abergel, J., Warner, R. et al. Percutaneous closure of a patent foramen ovale in left-sided carcinoid heart disease. Nat Rev Cardiol 4, 455–459 (2007). https://doi.org/10.1038/ncpcardio0944

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