Table of contents
July 2006 Volume 3 No 7
Editorial
Viewpoint
The future of left ventricular assist device therapy in adults
346Major advances have been seen both in the development and design of left ventricular assist devices. As a result, the indications for use have increased substantially. In this month's Viewpoint, Jonathan Chen, Yoshifumi Naka and Eric Rose explore the clinical promise and the current technical barriers of widespread application of left ventricular assist devices as destination therapy.
doi:10.1038/ncpcardio0600 | Full Text | PDF (102K)
Research Highlights
Structural and functional cardiac consequences of obstructive sleep apnea
348doi:10.1038/ncpcardio0561 | Full Text | PDF (101K)
New role for MMP-9 in neurovascular remodeling after stroke
348L-arginine therapy following myocardial infarction is ineffective and possibly unsafe
348Preprocedural clopidogrel increases bleeding in off-pump CABG
349doi:10.1038/ncpcardio0564 | Full Text | PDF (102K)
Kidney function level can be used to predict survival among patients with CVD
349doi:10.1038/ncpcardio0565 | Full Text | PDF (100K)
Warfarin is not appropriate in all patients with AF-associated ischemic stroke
350doi:10.1038/ncpcardio0566 | Full Text | PDF (103K)
Lipid-lowering PCSK9 sequence variants protect against coronary heart disease
350Detection of high-risk atherosclerotic plaques by palpography
350Folic acid and B vitamins fail to reduce major cardiovascular risk
351doi:10.1038/ncpcardio0569 | Full Text | PDF (101K)
Intensive rosuvastatin therapy leads to regression of atherosclerosis
351Resolution of migraine headaches after transcatheter closure of patent foramen ovale
353doi:10.1038/ncpcardio0573 | Full Text | PDF (100K)
Practice Points
Can intensive statin therapy cause regression of coronary atherosclerosis?
354doi:10.1038/ncpcardio0604 | Full Text | PDF (100K)
Is facilitated percutaneous coronary intervention superior to primary percutaneous coronary intervention?
356Can fondaparinux safely prevent the occurrence of venous thromboembolism in acutely ill medical patients?
358doi:10.1038/ncpcardio0582 | Full Text | PDF (101K)
Should aprotinin continue to be used during cardiac surgery?
360doi:10.1038/ncpcardio0578 | Full Text | PDF (104K)
Can brain natriuretic peptide levels aid diagnosis in children with congenital heart disease?
362Is rimonabant a safe and effective therapy for sustained weight loss and improved cardiometabolic risk factors?
364Reviews
Diastolic ventricular interaction: from physiology to clinical practice
368Since the ventricles share a common septum, interaction between them is inevitable. Performance of each ventricle is influenced by the compliance, filling volume and pressure of the other, as well as by external constraints from the pericardium. In this review, the role of direct diastolic ventricular interaction is explored in various cardiovascular disorders.
doi:10.1038/ncpcardio0584 | Full Text | PDF (274K)
Technology Insight: use of ventricular assist devices in children
377Although mechanical circulatory support has been used in children for many years, the development of implantable devices and improvements in extracorporeal support have provided viable options for bridging to transplantation or even to recovery. Hetzer and Stiller share their experience with the technology and techniques and discuss the decision-making processes.
doi:10.1038/ncpcardio0575 | Full Text | PDF (336K)
Drug Insight: clopidogrel nonresponsiveness
387Clopidogrel is widely used during percutaneous coronary intervention and to treat acute coronary syndromes. Nonresponsiveness and variability in responsiveness to clopidogrel therapy have been noted in numerous studies, and could put some patients at risk of repeat thrombotic events. The possible mechanisms and ways to overcome poor response to clopidogrel are discussed here.
doi:10.1038/ncpcardio0602 | Full Text | PDF (209K)
Case Study
Aortic thrombus and pulmonary embolism in a patient with hyperhomocysteinemia
396doi:10.1038/ncpcardio0601 | Full Text | PDF (246K)
