Table of contents
June 2006 Volume 3 No 6
Editorial
Viewpoint
Are we lowering LDL cholesterol sufficiently?
290A huge body of evidence now supports aggressive LDL cholesterol lowering to reduce cardiovascular risk, but what LDL cholesterol target level should be recommended? Here, Philip Barter and Kerry-Anne Rye examine the safety issues associated with achieving very low levels of LDL cholesterol and whether it is feasible to achieve very low levels in all high-risk people.
Research Highlights
LMWH therapy after mechanical heart valve replacement
292Risk factors predict survival and likelihood of cardiovascular events
292Noninvasive and long-term monitoring of pressure in abdominal aortic aneurysm sacs
292Dyslipidemia prevalence, treatment and control in a multiethnic population
293Percutaneous retrograde transarterial aortic valve implantation successful
293Is percutaneous heart valve replacement a feasible option for inoperable aortic stenosis?
294Key themes in reducing door-to-balloon times in patients with STEMI
294Brain natriuretic peptide is a marker of diastolic wall stress in heart failure
295Prehypertension and cardiovascular disease in high-risk individuals: the ARIC study
295Cangrelor inhibits platelet activation in patients undergoing PCI
295Rotterdam Study confirms that many myocardial infarctions are clinically unrecognized
296Are patients with rheumatoid arthritis prone to accelerated atherosclerosis?
296Optimum duration of clopidogrel pretreatment before PCI
297Practice Points
Is antiplatelet therapy safe after intracerebral hemorrhage?
298How do unfractionated and low-molecular-weight heparin compare after ST-segment elevation MI?
300Does neuroprotection with NXY-059 improve patient outcome after acute ischemic stroke?
302Can dobutamine stress echocardiography predict patient outcome after acute myocardial infarction?
304Reviews
Infective endocarditis: diagnosis and management
310Despite imaging advances, diagnosis of infective endocarditis is not simple, and uncertainty about whether a surgical or nonsurgical approach is best and the timing of intervention can hamper therapy. In this Review, Saptarsi Haldar and Patrick O'Gara discuss the major features of diagnosis and therapy and make recommendations based on the available data.
doi:10.1038/ncpcardio0535 | Full Text | PDF (190K)
Drug Insight: statin use in the elderly
318More than 80% of the US elderly population dies from coronary heart disease, but the benefits of statin therapy are not realized. These drugs are frequently underprescribed to elderly patients because few relevant age-specific data are available. This Review draws together the findings from major studies and assesses the value of statin use in the elderly.
doi:10.1038/ncpcardio0558 | Full Text | PDF (247K)
Technology Insight: clinical role of magnetic resonance angiography in the diagnosis and management of renal artery stenosis
329Improvement is still needed in the diagnosis of renal artery stenosis, which is the most common treatable cause of secondary hypertension. An accurate functional and morphological characterization of the disease might assist in management of patients. The value of magnetic resonance angiography in this setting is discussed.
doi:10.1038/ncpcardio0556 | Full Text | PDF (337K)
Case Study
Lupus anticoagulant and ischemic myocardial microangiopathy in rheumatoid arthritis
339doi:10.1038/ncpcardio0576 | Full Text | PDF (224K)
